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  • Marianne J. Middelveen, MDes

Marianne J. Middelveen, MDes

Marianne J Middelveen, MSc, MDes

Scientific Advisory Board
Alberta, Canada
Veterinary Microbiologist

Biography

Marianne Middelveen is a microbiologist and a medical mycologist in Calgary, Alberta, Canada currently working in the field of Veterinary Microbiology and specializing in bovine mastitis. She received post-graduate degrees in Microbial and Biochemical Science and in Environmental Science from Georgia State University and University of Calgary, respectively. She has been involved in research projects at the Centro Amazonico para Investigacion y Control de Enfermedades Tropicales, Puerto Ayacucho, Territorio Federal Amazonas (Edo. Amazonas), Venezuela; Instituto de Medicina Tropical, Universidad Central de Caracas, Caracas, Venezuela; Georgia State University, Atlanta, Georgia; Centers for Disease Control, Atlanta, Gerogia; University of Calgary, Faculty of Medicine, Department of Microbiology and Infectious Diseases, Calgary, Alberta. She became interested in Lyme disease after discovering she had the disease in 2011. As a volunteer, she has been involved in research related to Lyme disease on behalf of the Canadian Lyme Disease Foundation.

Ms. Middelveen’s interest in Morgellons began when she came across the website of Ginger Savely, DNP. Ground-breaking articles on Morgellons co-authored by Middelveen and Raphael Stricker, MD were published in Nov., 2011 and May, 2012. Research is continuing from this team and will be submitted to peer- reviewed medical journals for publication when completed.

Abstract

Topic 1: A look inside the matchbox: what is relevant and what isn’t

Morgellons disease (MD) is a dermopathy. It is typified by the presence of ulcerative lesions that are associated with the formation of multicolored filaments that lie under, are embedded in, or project from skin. MD is considered by many to be a delusional disorder. In contrast, recent studies show that it is associated with tickborne infection, that the filaments are keratin and collagen, and that they are the products of keratinocytes and fibroblasts.

Visual, antigenic and genetic evidence of spirochetal infection has been demonstrated in tissues from MD patients. Infections with Borrelia burgdorferi sensu stricto infections predominate, but. other spirochetes including Borrelia garinii, Borrelia miyamotoi, Borrelia hermsii, and Treponema denticola have also been detected in specimens taken from MD patients.

In addition to fibers, some MD Patients report other unusual skin findings: hexagonal crystals, glitter, gel, slime, fuzzballs, specks, cocoons, bugs, and worms. This presentation will focus on what is found in Morgellons skin samples and will explore the relevance of these findings.


Topic 2: A Critique of the CDC Morgellons study, “Clinical, Epidemiologic, Histopathologic, and Molecular Features of an Unexplained Dermopathy”

Background

A Critique of the CDC Morgellons study, “Clinical, Epidemiologic, Histopathologic, and Molecular Features of an Unexplained Dermopathy”

Members of the public and providers who had concerns about this illness had contacted the Centers for Disease Control and Prevention (CDC). In January 2008, the CDC began an investigation to better understand MD. The CDC referred to the condition as “an unexplained apparent dermopathy” and then partnered with Kaiser Permanente (KP), including Kaiser Permanente Northern California (KPNC), and the Armed Forces Institute of Pathology (AFIP) to investigate the condition. The results were published over 4 years later in the paper: Clinical, Epidemiologic, Histopathologic and Molecular Features of an Unexplained Dermopathy.

This presentation is a point-by-point discussion of the CDC study.